I think more information is needed before we can provide any kind of answer.   Are you looking for something that would "optimize" access to the database in an application?  Is this a web app?   At the highest level, nothing can do more for performance than a good database…

We faced this same decision a year ago, and decided on Simplivity. We regret it for one reason. The support is non-existent. We were promised many things prior to the purchase, and none of them materialized. HPE has completely let us down.