Definitely look at Compuware's aaNPM Data Centre Real User Monitoring (DCRUM). There are a number of benefits when you monitor on the wire (either by TAP or SPAN) rather than polling devices for stats.

Cons for all of them are that they only sample transactions and can't follow a single user from their device all the way through to the backend database or mainframe. Best using dynaTrace if you want true 100% end to end monitoring.