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Cortex XDR vs Microsoft Defender comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Apr 20, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.7
Cortex XDR enhances threat prevention, compliance, and cost efficiency, providing rapid ROI and improved security and user satisfaction.
Sentiment score
7.3
Organizations achieve financial gains and efficiency by using Microsoft Defender, eliminating third-party solutions, and enhancing security management.
They appreciate the rich telemetry data from the solution, as it provides in-depth threat identification.
I have seen a return on investment with Cortex XDR by Palo Alto Networks, as this product is offered at a minimal cost, and we can find a good ROI from it.
Without detection and protection measures, organizations would face substantial payments and reputational damage, including the necessity to inform customers about data breaches, potentially leading to loss of business.
We have seen a return on investment when using Microsoft Defender for Endpoint, as it saves labor by reducing the need for staff to focus on it.
The biggest return on investment for me when using Microsoft Defender for Endpoint is the time saving.
 

Customer Service

Sentiment score
6.6
Palo Alto Networks' customer service receives mixed reviews due to language barriers, response times, and inconsistent technical support quality.
Sentiment score
6.6
Microsoft's Defender for Endpoint support is generally effective but experiences vary; premium options offer swift, knowledgeable assistance.
Every vendor has similar support; it depends on how the case is handled and raised.
Their support is efficient and responsive whenever I raise a ticket through my portal.
I would rate technical support from Palo Alto on a scale from one to ten as an eight, as I find it good.
The level-one support seems disconnected from subject matter experts.
I rate Microsoft support 10 out of 10.
Due to our size, we don't have access to direct technical support, but the knowledge base, Microsoft Learn, and the articles available are really good.
 

Scalability Issues

Sentiment score
7.6
Cortex XDR excels in scalability and adaptability across environments, supporting diverse systems with seamless deployment and reliable expansion.
Sentiment score
7.6
Microsoft Defender for Endpoint efficiently scales with diverse enterprises, integrates seamlessly with Microsoft products, supporting growth effectively.
We managed to scale it out in a short amount of time, with two months of planning and three months of implementation on 10,000 computers.
Microsoft Defender for Endpoint is scalable enough to handle various devices across environments, whether they are laptops, Android devices, or operating in hybrid environments.
Compatibility is its main feature.
 

Stability Issues

Sentiment score
8.0
Cortex XDR by Palo Alto Networks is stable and reliable, with quick bug fixes and consistent performance across platforms.
Sentiment score
7.9
Microsoft Defender for Endpoint is praised for stability, efficiency, and low resource impact, despite minor occasional bugs.
Cortex XDR is stable, offering high quality and reliable performance.
For the last 11 months, we haven't faced any outage issues, so it is a stable product.
I haven't seen any outages with Microsoft.
I rate Defender 10 out of 10 for stability.
Defender for Endpoint is extremely stable.
 

Room For Improvement

Users find Cortex XDR challenging due to integration issues, high memory usage, limited features, and a need for improvements.
Microsoft Defender for Endpoint struggles with support, integration, UI, performance issues, and lacks essential features and platform support.
The inclusion of this feature would allow the application of DLP policies alongside antivirus policies via a single agent and console, making it more competitive as other OEMs often offer DLP solutions as part of their antivirus products.
If the per GB data could be provided at a certain level free of cost or at the same cost which the customer is taking for the entire bundle, that would be better.
Cortex XDR could improve its sales support team, including better commission structures and referral programs.
Repeated interactions are necessary due to Level One's lack of tools and knowledge, hindering efficient problem-solving and negatively impacting our experience with Microsoft support.
We use Microsoft partners to help govern the platform, and as part of an alliance, we want to gather data from each tenant and combine them for a complete view.
Providing more detailed information on how Microsoft Defender for Endpoint detects vulnerabilities.
 

Setup Cost

Cortex XDR offers flexible licensing, valued for complex security needs, but perceived as costly and variable in international markets.
Microsoft Defender for Endpoint offers cost-effective, flexible pricing options integrated with Microsoft services, including discounts for education and volume.
Cortex XDR is perceived as expensive by some customers, yet offers dynamic pricing.
Compared to competitors such as CrowdStrike and Sophos, the pricing of Cortex XDR by Palo Alto Networks is similar to CrowdStrike but more expensive than Sophos.
Given our extensive Microsoft licensing, transitioning to Defender for Endpoint did not affect licensing costs.
It costs $15 per VM for the P2 plan, which is seen as affordable for customers.
The pricing, setup, and licensing were very easy and simple.
 

Valuable Features

Cortex XDR ensures comprehensive protection with AI-driven analytics, multi-layered threat detection, and seamless integration, enhancing security management.
Microsoft Defender for Endpoint offers seamless integration, real-time protection, and automated response, ensuring robust security with minimal impact.
It incorporates AI for normal behavior detection, distinguishing unusual operations.
The product provides automation responses in case of a threat attack, severity assessments, centralized manageability, and comprehensive compliance features, resulting in reduced costs.
If a user doesn't click any link within 30 days and on the 31st day clicks a new link, Cortex XDR immediately alerts us that this user has clicked on an uncommon link or their behavior is uncommon.
Defender for Endpoint's coverage across different platforms in our environment is pretty good. We have devices running Linux, Mac OS, Windows, iOS, and Android. It covers all of them.
Microsoft Defender for Endpoint provides a unified management interface allowing customers to manage their on-premises and hybrid infrastructures from a single pane.
One of the best features of Microsoft Defender for Endpoint is its database for identifying zero-day attacks or malware attacks.
 

Categories and Ranking

Cortex XDR by Palo Alto Net...
Ranking in Endpoint Protection Platform (EPP)
4th
Average Rating
8.4
Reviews Sentiment
7.4
Number of Reviews
91
Ranking in other categories
Extended Detection and Response (XDR) (7th), Ransomware Protection (2nd), AI-Powered Cybersecurity Platforms (4th)
Microsoft Defender for Endp...
Ranking in Endpoint Protection Platform (EPP)
1st
Average Rating
8.2
Reviews Sentiment
7.1
Number of Reviews
197
Ranking in other categories
Advanced Threat Protection (ATP) (4th), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (4th)
 

Mindshare comparison

As of July 2025, in the Endpoint Protection Platform (EPP) category, the mindshare of Cortex XDR by Palo Alto Networks is 3.7%, down from 4.9% compared to the previous year. The mindshare of Microsoft Defender for Endpoint is 10.4%, down from 14.0% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Endpoint Protection Platform (EPP)
 

Featured Reviews

NiteshSharma - PeerSpot reviewer
Automated threat response and behavioral control improve security measures
I recommend adding a data loss prevention (DLP ( /categories/data-loss-prevention-dlp )) solution to Cortex XDR ( /categories/extended-detection-and-response-xdr ) by Palo Alto Networks. The inclusion of this feature would allow the application of DLP ( /categories/data-loss-prevention-dlp ) policies alongside antivirus policies via a single agent and console, making it more competitive as other OEMs often offer DLP solutions as part of their antivirus products. Additionally, multi-tenancy and multi-cloud features are not available and should be considered for inclusion.
John Rallo - PeerSpot reviewer
Offers excellent visibility into vulnerabilities and the attack surface itself
Attack surface reduction and limiting attack surface vectors are valuable features. It's helpful to isolate specific devices and get super granular with the features they offer. The visibility into the attack surface is good. It gets highly granular. I don't work on that side, but the people who do tell me they get more visibility.
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Answers from the Community

Ammar Jibarah - PeerSpot reviewer
Dec 7, 2022
Dec 7, 2022
I have not used Microsoft Defender and only used Cortex XDR by Palo Alto Networks. My experience with Cortex is not good as you need to whitelist each and every exe file of each adn every computer. My recommendation for you is to go for Cynet360 MDR which is far better than Cortex in terms of auto detection and remediation. You will get genuine alert.
2 out of 4 answers
Zubair Ahmad - PeerSpot reviewer
Sep 7, 2022
I have not used Microsoft Defender and only used Cortex XDR by Palo Alto Networks. My experience with Cortex is not good as you need to whitelist each and every exe file of each adn every computer. My recommendation for you is to go for Cynet360 MDR which is far better than Cortex in terms of auto detection and remediation. You will get genuine alert.
JH
Sep 7, 2022
I would go for the one with the best independent threat intelligence, a platform that allows you to change, add, move IT and Security infrastructure without impacting your security platform.  I would also place a close attention to storage costs, service levels and the number of resources providing human intelligence on top of machine intelligence for investigation and incident response, all in one platform.  But I am biased ;-)
 

Top Industries

By visitors reading reviews
Computer Software Company
14%
Financial Services Firm
9%
Manufacturing Company
8%
Government
7%
Computer Software Company
13%
Educational Organization
10%
Financial Services Firm
8%
Government
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

Cortex XDR by Palo Alto vs. Sentinel One
Cortex XDR by Palo Alto vs. SentinelOne SentinelOne offers very detailed specifics with regard to risks or attacks. The ability to reverse damage caused by ransomware with minimal interruptions to...
Comparing CrowdStrike Falcon to Cortex XDR (Palo Alto)
Cortex XDR by Palo Alto vs. CrowdStrike Falcon Both Cortex XDR and Crowd Strike Falcon offer cloud-based solutions that are very scalable, secure, and user-friendly. Cortex XDR by Palo Alto offers ...
How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
What do you like most about Microsoft Defender for Endpoint?
The most valuable aspect lies in its automation capabilities, particularly within security automation.
 

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps
Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

CBI Health Group, University Honda, VakifBank
Petrofrac, Metro CSG, Christus Health
Find out what your peers are saying about Cortex XDR by Palo Alto Networks vs. Microsoft Defender for Endpoint and other solutions. Updated: July 2025.
861,524 professionals have used our research since 2012.