I think the presentation layer could be improved - currently, it's too complex, and there are too many features cluttered all over the screen. Alfresco also needs to be well-integrated with Microsoft, as it's currently a nuisance for customers who rely on Microsoft's Office 365 solutions. There's a pretty obvious gap in the overlap between SharePoint when customers go to O365 and are presented with the SharePoint license and storage to start with, which Alfresco isn't taking advantage of.
