The main differences between Collibra Lineage and Informatica are significant, particularly for small to mid-sized organizations. First, Informatica requires a dedicated team, which incurs a huge cost, making it less suitable for smaller organizations. Second, Informatica's tools are very scattered. For instance, to create a domain, you need to use Axon, and then for lineage, you must use EDC. For profiling, Informatica Developer or Analyst is required. These different tools are not well-connected to display everything on one screen. While Informatica is trying to improve with its cloud version, not many users have adopted it yet. These are the two main areas where Informatica lags.