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Microsoft Defender for Office 365 vs Proofpoint Targeted Attack Protection comparison

 

Comparison Buyer's Guide

Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Proofpoint Targeted Attack ...
Ranking in Advanced Threat Protection (ATP)
28th
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
1
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of July 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 8.4%, down from 13.8% compared to the previous year. The mindshare of Proofpoint Targeted Attack Protection is 1.8%, down from 2.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
KC
Dynamic runtime engine and good protection, but needs better support and a single console
We have two to three issues per month. We contact Proofpoint's customer support for these issues. I am a major point of contact for support. If I am not able to resolve an issue, we will be reaching out to them. Proofpoint can take a couple of days to get back. I also deal with other applications from Okta and Microsoft, and we get the support within a couple of hours. There is a lot of difference between a couple of hours and a couple of days. So, Proofpoint's support should be improved. Okta and Microsoft are also able to do a Zoom or video call, but Proofpoint provides support only through email communication. Only if you request, it would be a Zoom or video session.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Safe attachments, safe links, policies, and the ability to protect from zero-day threats are the most valuable features."
"Microsoft Defender for Office 365 facilitates efficient management and updates through the cloud. We do not have to worry about incompatibilities. It just works."
"Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the individuals within our organization who are affected."
"The most valuable feature is the integration. It's a single console, so we don't have to switch around between multiple products. Another valuable feature is the ease of operations and maintenance."
"The initial setup is straightforward. You just add the license, click it, and then you can set up the rules. It is quite simple."
"Defender for Office 365 has helped eliminate having to look at multiple dashboards and that is the aspect I like most about it. It is simpler, effective, and convenient. The users like the process efficiency."
"I would say that 90% of the spam and phishing attack emails get blocked right off the bat."
"Microsoft Defender for Office 365's most valuable feature is its performance."
"It has a dynamic runtime engine, which gives it an advantage over Prisma that has a static engine. In Prisma, we have to do additional malware analysis, which is not required in Proofpoint."
 

Cons

"It would be better if it were more scalable. It depends on the architecture, but we would like to make it more scalable for both data centers."
"We need to be able to whitelist data at the backend."
"Microsoft Defender for Office 365 should be more proactive."
"The changes to customer service, specifically the new model for support agreements, are not favorable."
"Microsoft needs to broaden its global support presence by establishing teams of subject-matter experts in all regions."
"I'd like some additional features any product can give me to protect our environment in a better way."
"Microsoft sometimes has downtime, and we'll get several incidents coming in back to back. We have a huge backlog of notifications, many of which may be false positives. However, there might be serious alerts, so we can't risk dismissing all of them at once."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"We are using the TRAP console that has a Linux-based UI, which is not user-friendly. The TAP console looks very advanced. Currently, we are maintaining three different consoles, and it is sometimes hard to switch between them or try to grab the data."
 

Pricing and Cost Advice

"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"It's a user-base subscription."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"The product is very expensive."
Information not available
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
8%
Manufacturing Company
8%
Government
6%
Manufacturing Company
12%
Computer Software Company
12%
Financial Services Firm
11%
Healthcare Company
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
No data available
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published. It's essential to enhan...
Ask a question
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Also Known As

MS Defender for Office 365
Targeted Attack Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Brinker Capital
Find out what your peers are saying about Palo Alto Networks, Microsoft, Fortinet and others in Advanced Threat Protection (ATP). Updated: July 2025.
863,679 professionals have used our research since 2012.