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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
20th
Average Rating
8.0
Reviews Sentiment
7.0
Number of Reviews
13
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
1st
Average Rating
8.2
Reviews Sentiment
7.1
Number of Reviews
48
Ranking in other categories
Advanced Threat Protection (ATP) (1st), Microsoft Security Suite (11th)
 

Mindshare comparison

As of March 2025, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.0%, down from 1.2% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 13.5%, down from 19.7% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Mike Bulyk - PeerSpot reviewer
Can quickly identify, track, tag, and categorize internal emails. Reporting accessibly via the main dashboard would be a great addition.
If Cisco could continue to develop integrations, whether it's internal tooling, Threat Grid, or AMP reporting which could be accessible via a single web page, that would be helpful. This would essentially add additional context on messages as well as files or links being detected. Potentially adding additional context on why certain messages are tagged as spam or malware. In our case, malware hasn't been detected yet, but spam certainly has been. Knowing what engines or which components of the message make it identifiable as spam, that could be useful. Additional context and reporting accessibly via the main dashboard would be great. There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting.
Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"Secure Email Threat Defense's scalability is good."
"I highly recommend it as one of the best choices."
"The solution is stable."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"The product offers protection, email security, anti-spam, and antivirus."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"It has an efficient email filtering feature."
"The deployment capability is a great feature."
"Defender helps us prioritize threats across our organization."
"Microsoft Defender for Office 365's most valuable feature is its performance."
"Microsoft Defender for Office 365 facilitates efficient management and updates through the cloud. We do not have to worry about incompatibilities. It just works."
"Some of the valuable features on the email side are anti-phishing, anti-malware, and Safe Links."
"Our customers are satisfied with Defender for 365 because Microsoft products are easy to use and customize to meet the client's needs. Everything is in one place, so we can adjust policies as needed for phishing, DLP, ATP, or any other security features that our clients want to apply."
"Microsoft Defender for Office 365 helps people to work remotely. It is a secure solution. We don't need to use our company's computers or get VPN connections to the networks. I can control how they share screens and what they send to the devices. It keeps our organizations confidential and sensitive information safe."
"The basic features are okay and I'm satisfied with the Defender."
 

Cons

"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"This solution could be improved by integration with Sandbox."
"The solution is a bit expensive."
"One area for improvement is integration. For example, when it comes to external SaaS platforms, we were not able to get a lot of information on integrations with such apps for security and authentication."
"The only thing they should improve is the licensing model. They should stop changing it. A year ago, the five features I mentioned were included in one product. Now, three of them are bundled into one product, and you have to pay extra for the other two. I don't mind paying extra, but I don't want them to change it every year or every six months. I need to know what I'm looking at and not worry about it next year."
"There's room for improvement regarding the time frame for retrieving emails."
"Microsoft wants its well-paying customers to finish testing some of its half-baked products, find bugs, and report bugs back to Microsoft's team, which is a little frustrating for those who have to manage it and roll it up to thousands of people across the organization."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"Microsoft Defender for Office 365 should be more proactive."
"Sometimes, phishing emails manage to pass through the filter, so the system needs to enhance its phishing email detection capabilities."
"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats. For example, information about best practices on how to protect their own devices against hackers and scammers, such as educational information or training. This would help others have a better understanding of cyber security. Additionally, there can be more security features added."
 

Pricing and Cost Advice

"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"It is expensive compared to other vendors."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"I know that the product is incredibly expensive."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"The product is very expensive."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
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Top Industries

By visitors reading reviews
Computer Software Company
37%
Healthcare Company
7%
Manufacturing Company
6%
Comms Service Provider
6%
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher side. That said, you get what you pay for.
What needs improvement with Secure Email Threat Defense?
The physical appliance has been discontinued, although the platform still exists. Improvements here and there could be beneficial, however, there aren't too many needed. Some potential improvements...
What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
I don't have detailed specifics on pricing, setup cost, or licensing.
What needs improvement with Microsoft Defender for Office 365?
I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost.
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: March 2025.
842,388 professionals have used our research since 2012.