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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
21st
Average Rating
8.6
Reviews Sentiment
6.5
Number of Reviews
23
Ranking in other categories
Secure Web Gateways (SWG) (15th), Data Loss Prevention (DLP) (20th), Cloud Access Security Brokers (CASB) (11th), Distributed Denial-of-Service (DDoS) Protection (7th), Software Defined WAN (SD-WAN) Solutions (13th), Access Management (13th), Bot Management (3rd), ZTNA as a Service (9th), ZTNA (4th), Secure Access Service Edge (SASE) (10th), Remote Browser Isolation (RBI) (3rd)
Cisco Secure Email Threat D...
Ranking in Email Security
19th
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
62
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of April 2026, in the Email Security category, the mindshare of Cloudflare One is 1.5%, down from 1.7% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.1% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 7.3%, down from 13.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3657.3%
Cisco Secure Email Threat Defense1.1%
Cloudflare One1.5%
Other90.1%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
reviewer2541525 - PeerSpot reviewer
Principal Cyber Prevent and Defense Engineer at a comms service provider with 1,001-5,000 employees
Clawback feature performs well but analytics and integration capabilities need improvement
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty in sending logs to our SIEM. Cisco Secure Email Threat Defense's flexibility could be enhanced while it mostly integrates with cloud solutions, but not on-premise. The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious. Regarding room for improvement, the significant number of false positives should be addressed. The solution does not adapt to behavioral analytics and does not make changes when it sees a pattern.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"For Cloudflare Access, I am using the free plan...The most valuable feature is their protection."
"What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection."
"It will take the blow rather than our applications should an attack occur."
"Clover is the best product globally."
"The best feature is rate limiting. If I'm expecting 500 visits per hour, Cloudflare will limit the requests if I suddenly get 50,000."
"This solution is easy to understand and easy to configure."
"It is a stable solution."
"Cloudflare DDoS is better than its competitors for its security, deployment, and scalability."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Secure Email Threat Defense's scalability is good."
"It has an efficient email filtering feature."
"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"Currently, the ease of deployment is the low-hanging fruit for Cisco email security."
"It's very easy to deploy and configure."
"The features I appreciate most about Microsoft Defender for Office 365 are admin notifications for potential threats along with protecting our Microsoft apps such as Outlook from potential phishing attacks."
"Defender for 365 is a comprehensive cloud-based solution. The value of the cloud is that you aren't alone. Threat intelligence and analytics are shared in the cloud. We don't have to find the solution alone. If you face an unknown threat with traditional solutions like Trend Micro and Symantec, you need to open a case and send your information to them to analyze forensically and identify the source of the attack."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"The ability to respond to threats if very important."
"It has helped us in improving our security posture; it detects any kind of attack or abnormal behavior in accessing the system and sends an alert to the administrator who can check, understand, and review on time to ensure that all activities are legit."
"Microsoft Defender for Office 365 has significantly reduced the phishing impact on users and improved the detection of malicious emails, which has also improved visibility for my SOC team."
"The most valuable feature of Microsoft Defender for Office 365 is the ease of use."
"Microsoft Defender for Office 365 has improved my organization's security. It makes it easier to manage the infrastructure without the help of third-party applications."
 

Cons

"Cloudflare Zero Trust Platform needs to improve its documentation. It took time to do the implementation."
"From a logging perspective, it is still a bit difficult to see exactly what users are being blocked with the current views."
"They don't have a person to provide support for customers using the solution under their free plan."
"Our customers no longer use Cloudflare because its service is subpar."
"Feedback could be enhanced."
"The tool should provide on-premise versions. Currently, all versions are cloud-based."
"Our customers no longer use Cloudflare because its service is subpar."
"The initial onboarding was causing us some confusion."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."
"The physical appliance has been discontinued, although the platform still exists."
"This solution could be improved by integration with Sandbox."
"Several simulation options are available within 365, and the phishing simulation could be better."
"The XDR dashboard has room for improvement."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"I'd like some additional features any product can give me to protect our environment in a better way."
"There needs to be an improvement in having the product work across multiple operating systems and have better support for non-Microsoft file types."
"There's room for improvement regarding the time frame for retrieving emails."
"It is not up to the mark in comparison with Wiz or Palo Alto."
"In one of the reports I can get the exact place where a vulnerable file resides. But for that, I need to explicitly go into the device and check. If they could include that file part in the report, without my having to go to the device itself, that would help."
 

Pricing and Cost Advice

"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"The solution's pricing lacks transparency."
"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"The prices are slightly expensive."
"The solution is not that expensive."
"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"Cloudflare Zero Trust Platform's pricing is good."
"The feedback from vendors and customer is that it is expensive."
"The solution’s pricing is manageable."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"I know that the product is incredibly expensive."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"The pricing has become expensive."
"The pricing is normal. Considering its popularity, it's not overpriced."
"It's a user-base subscription."
"The product is expensive."
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Top Industries

By visitors reading reviews
Construction Company
21%
Comms Service Provider
10%
Financial Services Firm
8%
Manufacturing Company
6%
Marketing Services Firm
12%
Manufacturing Company
8%
Healthcare Company
8%
Computer Software Company
7%
Computer Software Company
12%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise2
Large Enterprise11
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business25
Midsize Enterprise10
Large Enterprise31
 

Questions from the Community

What needs improvement with Cloudflare Access?
Cloudflare Access has strong integration with Microsoft, among other platforms. However, when it comes to Kaspersky, ...
What is your primary use case for Cloudflare Access?
Cloudflare Access provides secure access to internal applications for employees, external members of the organization...
What advice do you have for others considering Cloudflare Access?
Cloudflare Access is one of the best integrations available. While about two hundred vendors offer similar services, ...
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, ...
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new ...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat De...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking ...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: April 2026.
889,855 professionals have used our research since 2012.