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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
23rd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of September 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 5.2%, down from 11.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3655.2%
Cisco Secure Email Threat Defense1.1%
Other93.7%
Email Security
 

Featured Reviews

NM
Enginner at Millennium Information Technologies
Has faced challenges with configuration, taking actions, and learning curve but benefits from centralized management and good technical support
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, are limited as ETD only supports sending audit logs. Customers have requirements for other system logs as well, which should be developed from their side. Another customer request is to restrict the IPs that can log in, which cannot be done from Cisco Secure Email Threat Defense yet. Any user with login details can log in. We can restrict the IPs in Cloud Mail Gateways, but not from Cisco Secure Email Threat Defense. It would be beneficial to improve this feature. Cisco Secure Email Threat Defense can take actions, such as requesting O365 to quarantine mail. In that case, the customer requires notification to the recipient from Cisco Secure Email Threat Defense. This option would be valuable if available. The real-time threat intelligence of Cisco Secure Email Threat Defense is an AI-based classification. It took one to two months to optimize the classification, but we still experience some false positives. Reducing the learning period would be beneficial. The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned. Reducing the learning time would be much better. Additional features desired in the next release include IP restrictions and user logging IP restrictions, ensuring only the customer environment can log in to Cisco Secure Email Threat Defense. Logs forwarding needs improvement as currently it only has audit logs. In Cloud Mail Gateway, we can create an IPsec tunnel to forward logs. However, in Cisco Secure Email Threat Defense, there is no option, and we must do API integration to send logs. Only SIM can get logs; Syslog cannot retrieve them.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The solution is stable."
"Secure Email Threat Defense's scalability is good."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"It has an efficient email filtering feature."
"Cisco's technical support is very good."
"It's very easy to deploy and configure."
"We have seen a return on investment because if we would have received a phishing email, Microsoft Defender for Office 365 would help out to detect the threat instead of crashing down the whole company."
"The features I appreciate most about Microsoft Defender for Office 365 are admin notifications for potential threats along with protecting our Microsoft apps such as Outlook from potential phishing attacks."
"The most valuable feature is protection against malicious links, fishing, and impersonation. You can train people to be aware of these threats, but they're not always careful. When they're using their phones between meetings, they click on a link, and it's game over."
"I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection."
"The product is not resource-intensive."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"Safe attachments, safe links, policies, and the ability to protect from zero-day threats are the most valuable features."
"The technical support is good and quick to resolve issues."
 

Cons

"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The search area has room for improvement."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"The solution is a bit expensive. It could be cheaper."
"The physical appliance has been discontinued, although the platform still exists."
"Microsoft sometimes has downtime, and we'll get several incidents coming in back to back. We have a huge backlog of notifications, many of which may be false positives. However, there might be serious alerts, so we can't risk dismissing all of them at once."
"There is a different console for different things; I just want one consolidated console."
"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats. For example, information about best practices on how to protect their own devices against hackers and scammers, such as educational information or training. This would help others have a better understanding of cyber security. Additionally, there can be more security features added."
"They have moved features from one console to another. Things have been moved around in the interface and it takes me time to find where certain features are."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"Microsoft Defender for Office 365 should improve the troubleshooting tools. It's unclear whether the device is blocked at the firewall level or at the device itself. The granularity needed for troubleshooting is currently lacking. From my perspective, Microsoft should address this issue to benefit many users who likely share the same sentiment."
"One area for improvement is integration. For example, when it comes to external SaaS platforms, we were not able to get a lot of information on integrations with such apps for security and authentication."
"I was looking for some advanced features, like if I would receive an email that contains a legitimate file type, but the content is malicious, how I can protect against that?"
 

Pricing and Cost Advice

"The feedback from vendors and customer is that it is expensive."
"The solution’s pricing is manageable."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"The pricing has become expensive."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"The product is very expensive."
"The pricing is normal. Considering its popularity, it's not overpriced."
"It's a user-base subscription."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
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Top Industries

By visitors reading reviews
Marketing Services Firm
11%
Outsourcing Company
9%
Comms Service Provider
8%
Healthcare Company
8%
Computer Software Company
11%
Manufacturing Company
9%
Financial Services Firm
9%
Comms Service Provider
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: September 2026.
912,801 professionals have used our research since 2012.