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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
27th
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
53
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of October 2025, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 0.9% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 11.4%, down from 14.8% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 36511.4%
Cisco Secure Email Threat Defense1.1%
Other87.5%
Email Security
 

Featured Reviews

Enrique-Diaz Jolly - PeerSpot reviewer
Provides comprehensive threat protection with suggestions for modernizing controls
I use the email gateway as the core of the email exchange between the Internet and our domain. The email gateway serves as the email exchanger The product offers protection, email security, anti-spam, and antivirus. It includes threat intelligence with advanced malware protection and many…
Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The solution is stable."
"I highly recommend it as one of the best choices."
"The features and functionalities are much better than Microsoft's in-built Defender plan."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"It's very easy to deploy and configure."
"The product offers protection, email security, anti-spam, and antivirus."
"The DLP feature of Microsoft Defender for Office 365 is valuable, and we also use the DLP feature for email real-time detection."
"Microsoft Defender has a feature to protect each and every attachment. Even if it's an encrypted attachment, it will check for any potential threats."
"It’s easy to handle integrations, and we don't need a lot of people in our IT team."
"Defender for 365 is a comprehensive cloud-based solution. The value of the cloud is that you aren't alone. Threat intelligence and analytics are shared in the cloud. We don't have to find the solution alone. If you face an unknown threat with traditional solutions like Trend Micro and Symantec, you need to open a case and send your information to them to analyze forensically and identify the source of the attack."
"There are several features that I consider valuable."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"Defender for Office 365 has helped eliminate having to look at multiple dashboards and that is the aspect I like most about it. It is simpler, effective, and convenient. The users like the process efficiency."
"The most valuable feature of Microsoft Defender for Office 365 is the ease of use."
 

Cons

"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."
"The pricing could always be better."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"The physical appliance has been discontinued, although the platform still exists."
"There is room for improvement in terms of reporting."
"The pre-sales cost calculations could be more transparent."
"The visibility into threats is not up to the mark, as I do not have control. I rate my experience with Microsoft Defender for Office 365 as six out of ten due to troubleshooting and pricing concerns."
"The only thing they should improve is the licensing model. They should stop changing it. A year ago, the five features I mentioned were included in one product. Now, three of them are bundled into one product, and you have to pay extra for the other two. I don't mind paying extra, but I don't want them to change it every year or every six months. I need to know what I'm looking at and not worry about it next year."
"Several simulation options are available within 365, and the phishing simulation could be better."
"Configuring the default strategies and policies in Microsoft Defender for Cloud Apps generates a lot of noise and false positives."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"There is a different console for different things; I just want one consolidated console."
 

Pricing and Cost Advice

"The solution’s pricing is manageable."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"The pricing has become expensive."
"The pricing is normal. Considering its popularity, it's not overpriced."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"I know that the product is incredibly expensive."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
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Top Industries

By visitors reading reviews
Computer Software Company
19%
Healthcare Company
8%
Manufacturing Company
7%
Financial Services Firm
7%
Computer Software Company
15%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise8
Large Enterprise27
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
I think that Microsoft Defender for Office 365 could be improved if it could use VirusTotal to compare the programs or anything that I download. VirusTotal helps to identify viruses, malware, troja...
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: September 2025.
869,785 professionals have used our research since 2012.