No more typing reviews! Try our Samantha, our new voice AI agent.

Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

Why PeerSpot?
 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
23rd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (2nd), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of October 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 5.1%, down from 11.0% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3655.1%
Cisco Secure Email Threat Defense1.1%
Other93.8%
Email Security
 

Featured Reviews

GC
Senior Cybersecurity Engineer at a financial services firm with 11-50 employees
Provides robust email security features but requires improved modernization and complexity management
Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"I highly recommend it as one of the best choices."
"The product offers protection, email security, anti-spam, and antivirus."
"Secure Email Threat Defense's scalability is good."
"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"Cisco Cloud Mailbox is used for copying emails, anti-spamming, and securing the company's email, and we really enjoy the anti-spamming capabilities as well as the rejecting of bulk emails, which we can customize by adjusting the variables, and it is very user-friendly."
"Some of the valuable features on the email side are anti-phishing, anti-malware, and Safe Links."
"Microsoft Defender for Office 365's most valuable features are safe attachments and safe links."
"It definitely is a must for email protection and O365 app DLP, and combined with Microsoft Defender for Endpoint, Microsoft Defender for Identity, and MCAS, it provides a holistic solution for threat protection, email protection, O365 apps protection, and DLP for both internal and external risks."
"It also gives me good visibility because, with Defender, I'm using a Microsoft product to defend Microsoft products. The integration was really seamless and I have wide visibility because it picks up almost everything. Literally, I can see almost every activity that happens, from the e-mail to the workstation itself."
"The DLP feature of Microsoft Defender for Office 365 is valuable, and we also use the DLP feature for email real-time detection."
"The email protection is excellent, especially in terms of anti-phishing policies."
"My experience with customer support and technical support for Microsoft Defender for Office 365 has been excellent."
"Microsoft Defender for Office 365 is a stable solution."
 

Cons

"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."
"The solution is a bit expensive. It could be cheaper."
"The search area has room for improvement."
"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"The pricing could always be better."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"To improve Microsoft Defender for Office 365, it would be nice to have more accessibility for users to see on their end what they are doing that could cause a threat."
"There is a different console for different things; I just want one consolidated console."
"The XDR dashboard has room for improvement."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
"They have moved features from one console to another. Things have been moved around in the interface and it takes me time to find where certain features are."
"Microsoft should provide more documentation for users so they can self-educate. I would like to see more documentation for advanced security features."
"Configuring the default strategies and policies in Microsoft Defender for Cloud Apps generates a lot of noise and false positives."
"There needs to be an improvement in integrating the product to work across multiple operating systems, and to have better support for non-Microsoft file types."
 

Pricing and Cost Advice

"It is expensive compared to other vendors."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"I know that the product is incredibly expensive."
"The product is very expensive."
"The pricing has become expensive."
"The license is expensive because the cost is based on the number of users."
"The pricing is normal. Considering its popularity, it's not overpriced."
report
Use our free recommendation engine to learn which Email Security solutions are best for your needs.
918,614 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Marketing Services Firm
11%
Outsourcing Company
9%
Comms Service Provider
9%
Healthcare Company
9%
Computer Software Company
11%
Manufacturing Company
10%
Financial Services Firm
8%
Comms Service Provider
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: September 2026.
918,614 professionals have used our research since 2012.