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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
21st
Average Rating
8.6
Reviews Sentiment
6.5
Number of Reviews
23
Ranking in other categories
Secure Web Gateways (SWG) (15th), Data Loss Prevention (DLP) (20th), Cloud Access Security Brokers (CASB) (11th), Distributed Denial-of-Service (DDoS) Protection (7th), Software Defined WAN (SD-WAN) Solutions (13th), Access Management (13th), Bot Management (3rd), ZTNA as a Service (9th), ZTNA (4th), Secure Access Service Edge (SASE) (10th), Remote Browser Isolation (RBI) (3rd)
Cisco Secure Email Threat D...
Ranking in Email Security
19th
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
62
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of April 2026, in the Email Security category, the mindshare of Cloudflare One is 1.5%, down from 1.7% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.1% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 7.3%, down from 13.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3657.3%
Cisco Secure Email Threat Defense1.1%
Cloudflare One1.5%
Other90.1%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
reviewer2541525 - PeerSpot reviewer
Principal Cyber Prevent and Defense Engineer at a comms service provider with 1,001-5,000 employees
Clawback feature performs well but analytics and integration capabilities need improvement
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty in sending logs to our SIEM. Cisco Secure Email Threat Defense's flexibility could be enhanced while it mostly integrates with cloud solutions, but not on-premise. The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious. Regarding room for improvement, the significant number of false positives should be addressed. The solution does not adapt to behavioral analytics and does not make changes when it sees a pattern.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Cloudflare Access is a stable solution."
"It's the endpoint exposition. We don't need to expose our VPN server to the internet and need a zero-test solution. I can apply some conditional access to the endpoint that's connecting to our network to check their security policies or the security condition of their workstation. Once the workstation is trying to connect to my internal network, then I would like to check the discrete condition of these endpoints that are trying to access my internal network. We created some conditional access. We have CrowdStrike, to check if the CrowdStrike is installed, to check if it's updated, and to check for Windows updates. We created some conditional policies to check it."
"Cloudflare Access is part of the Zero Trust philosophy."
"The solution has different options that can be used to differentiate DDoS attacks."
"It will take the blow rather than our applications should an attack occur."
"Cloudflare DDoS is better than its competitors for its security, deployment, and scalability."
"It's a perfect solution from my perspective; it's easy to understand and easy to configure."
"What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection."
"The features and functionalities are much better than Microsoft's in-built Defender plan, and this product has helped us to protect our organization from any malware attack in the past."
"Cisco Secure Email Threat Defense's best features include user management of graymail, enhancing security awareness by allowing users to manage cold calls, sales-based items, and ensuring email compliance."
"On ease of use, it rates very high."
"The features and functionalities are much better than Microsoft's in-built Defender plan."
"It has an efficient email filtering feature."
"The product offers protection, email security, anti-spam, and antivirus."
"Secure Email Threat Defense's scalability is good."
"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"Microsoft Defender for Office 365 has significantly reduced the phishing impact on users and improved the detection of malicious emails, which has also improved visibility for my SOC team."
"The risk level notifications are most valuable. We get to know what kind of intrusion or attack is there, and we can fix a problem on time."
"Safe attachments, safe links, policies, and the ability to protect from zero-day threats are the most valuable features."
"At the moment we are satisfied with this product. It's a stable, scalable, and resilient solution for us."
"The email protection is excellent, especially in terms of anti-phishing policies."
"Microsoft Defender for Office 365's most valuable feature is its performance."
"The product is not resource-intensive."
"Microsoft Defender for Office 365 saves me time; it does save a lot of time, especially with the automation."
 

Cons

"Our subscription plan for the solution has a limitation of bot signatures."
"Lacks a VPN feature to provide a secure connection to the data center."
"The initial onboarding was causing us some confusion."
"They don't have a person to provide support for customers using the solution under their free plan."
"The tool should provide on-premise versions. Currently, all versions are cloud-based."
"Cloudflare One is not very powerful, but for what we require, it is basic and sufficient."
"Cloudflare Zero Trust Platform needs to improve its documentation. It took time to do the implementation."
"The software has automated alerts, but the automated alerts are not available in the mobile app."
"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"We encounter issues while searching for missing emails."
"The physical appliance has been discontinued, although the platform still exists."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"From a development point of view, if I wanted to do development on my actual machine where Defender is, the organization can set certain policies or Defender makes that prohibitive."
"The custom alerts have to improve a lot."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"The changes to customer service, specifically the new model for support agreements, are not favorable."
"We are always looking for other tools to increase automation on tasks. There can be better integration with other solutions, such as PowerPoint and email."
"One area for improvement is integration. For example, when it comes to external SaaS platforms, we were not able to get a lot of information on integrations with such apps for security and authentication."
"The visibility for the weaknesses in the system and unauthorized access can be improved."
"In one of the reports, I can get the exact place where a vulnerable file resides, but for that, I need to explicitly go into the device and check."
 

Pricing and Cost Advice

"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"Cloudflare Zero Trust Platform's pricing is good."
"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"The solution's pricing lacks transparency."
"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"The solution is not that expensive."
"The prices are slightly expensive."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"It is expensive compared to other vendors."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"The product is expensive."
"The pricing is normal. Considering its popularity, it's not overpriced."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"The license is expensive because the cost is based on the number of users."
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Top Industries

By visitors reading reviews
Construction Company
21%
Comms Service Provider
10%
Financial Services Firm
8%
Manufacturing Company
6%
Marketing Services Firm
12%
Manufacturing Company
8%
Healthcare Company
7%
Computer Software Company
7%
Computer Software Company
12%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise2
Large Enterprise11
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business25
Midsize Enterprise10
Large Enterprise31
 

Questions from the Community

What needs improvement with Cloudflare Access?
Cloudflare Access has strong integration with Microsoft, among other platforms. However, when it comes to Kaspersky, ...
What is your primary use case for Cloudflare Access?
Cloudflare Access provides secure access to internal applications for employees, external members of the organization...
What advice do you have for others considering Cloudflare Access?
Cloudflare Access is one of the best integrations available. While about two hundred vendors offer similar services, ...
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, ...
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new ...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat De...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking ...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: April 2026.
890,071 professionals have used our research since 2012.