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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
21st
Average Rating
8.6
Reviews Sentiment
6.5
Number of Reviews
23
Ranking in other categories
Secure Web Gateways (SWG) (15th), Data Loss Prevention (DLP) (20th), Cloud Access Security Brokers (CASB) (11th), Distributed Denial-of-Service (DDoS) Protection (7th), Software Defined WAN (SD-WAN) Solutions (13th), Access Management (12th), Bot Management (3rd), ZTNA as a Service (8th), ZTNA (3rd), Secure Access Service Edge (SASE) (10th), Remote Browser Isolation (RBI) (3rd)
Cisco Secure Email Threat D...
Ranking in Email Security
19th
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of April 2026, in the Email Security category, the mindshare of Cloudflare One is 1.5%, down from 1.7% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.1% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 7.3%, down from 13.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3657.3%
Cisco Secure Email Threat Defense1.1%
Cloudflare One1.5%
Other90.1%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
reviewer2541525 - PeerSpot reviewer
Principal Cyber Prevent and Defense Engineer at a comms service provider with 1,001-5,000 employees
Clawback feature performs well but analytics and integration capabilities need improvement
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty in sending logs to our SIEM. Cisco Secure Email Threat Defense's flexibility could be enhanced while it mostly integrates with cloud solutions, but not on-premise. The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious. Regarding room for improvement, the significant number of false positives should be addressed. The solution does not adapt to behavioral analytics and does not make changes when it sees a pattern.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Enables me to work from two locations."
"Cloudflare DDoS is better than its competitors for its security, deployment, and scalability."
"It's the endpoint exposition. We don't need to expose our VPN server to the internet and need a zero-test solution. I can apply some conditional access to the endpoint that's connecting to our network to check their security policies or the security condition of their workstation. Once the workstation is trying to connect to my internal network, then I would like to check the discrete condition of these endpoints that are trying to access my internal network. We created some conditional access. We have CrowdStrike, to check if the CrowdStrike is installed, to check if it's updated, and to check for Windows updates. We created some conditional policies to check it."
"Cloudflare Zero Trust Platform removes the risk of exposing the applications to the public."
"It is a stable solution."
"Cloudflare DDoS mitigates DDoS attacks."
"Clover is the best product globally."
"Cloudflare One has assisted in securing my remote workforce through a SASE solution with Cloudflare One and the Workers part, although I am not currently using the Workers component."
"Secure Email Threat Defense's scalability is good."
"The solution is stable."
"Cisco Cloud Mailbox is used for copying emails, anti-spamming, and securing the company's email, and we really enjoy the anti-spamming capabilities as well as the rejecting of bulk emails, which we can customize by adjusting the variables, and it is very user-friendly."
"It's very easy to deploy and configure."
"The advanced threat analytics and URL filtering in threat detection are good features that are working well."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Cisco Secure Email Threat Defense's best features include user management of graymail, enhancing security awareness by allowing users to manage cold calls, sales-based items, and ensuring email compliance."
"Cisco's technical support is very good."
"Microsoft Defender for Office 365 is a cloud-based email filtering service that helps protect our organization against unknown malware and viruses by providing robust zero-day protection and includes features to safeguard our organization from harmful links in real-time."
"There are several features that I consider valuable."
"The most valuable feature is protection against malicious links, fishing, and impersonation. You can train people to be aware of these threats, but they're not always careful. When they're using their phones between meetings, they click on a link, and it's game over."
"My experience deploying Microsoft Defender for Office 365 was seamless."
"The feature of Microsoft Defender for Office 365 that I like the most is probably the email features specifically, because those are the ones that a typical end user will accidentally click on a link not knowing what it is, and it'll catch it, and then it'll feed it over to Defender and stop the attack from happening before it actually can."
"The solution is very easy to use. All you have to do is to assign the license to the end-user and it's done. The customer will only have the feature activated, and the solution will monitor the emails to determine if they are a threat or not."
"My experience with customer support and technical support for Microsoft Defender for Office 365 has been excellent."
"Safe attachments, safe links, policies, and the ability to protect from zero-day threats are the most valuable features."
 

Cons

"The onboarding process can be improved a little bit."
"From a logging perspective, it is still a bit difficult to see exactly what users are being blocked with the current views."
"I would like them to include a VPN feature to provide a secure connection to the data center."
"When there are any dynamic changes in complex applications, the tool takes a lot of time, making its analytics-related area a major matter of concern where improvements are needed."
"They don't have a person to provide support for customers using the solution under their free plan."
"Operating and tuning the product is difficult."
"Our customers no longer use Cloudflare because its service is subpar."
"Our customers no longer use Cloudflare because its service is subpar."
"The search area has room for improvement."
"The solution is a bit expensive."
"This solution could be improved by integration with Sandbox."
"The solution is a bit expensive. It could be cheaper."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools."
"Microsoft Defender for Office 365 should be more proactive."
"Too many false positives and lacks an accurate capability to detect malicious SharePoint sites."
"They have moved features from one console to another. Things have been moved around in the interface and it takes me time to find where certain features are."
"One area for improvement is support, in terms of being able to reach them and, especially, technical support for configuration."
"The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster."
"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats. For example, information about best practices on how to protect their own devices against hackers and scammers, such as educational information or training. This would help others have a better understanding of cyber security. Additionally, there can be more security features added."
"In some situations, it has not been able to pick impersonated emails having no attachments. Technical support definitely has a scope for improvement."
"It would be better if it were more scalable. It depends on the architecture, but we would like to make it more scalable for both data centers."
 

Pricing and Cost Advice

"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"The solution's pricing lacks transparency."
"The solution is not that expensive."
"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"Cloudflare Zero Trust Platform's pricing is good."
"The prices are slightly expensive."
"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"It is expensive compared to other vendors."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"The pricing has become expensive."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"It's a user-base subscription."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
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Top Industries

By visitors reading reviews
Construction Company
23%
Comms Service Provider
10%
Financial Services Firm
8%
Computer Software Company
6%
Marketing Services Firm
12%
Manufacturing Company
8%
Construction Company
7%
Computer Software Company
7%
Computer Software Company
13%
Financial Services Firm
9%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise2
Large Enterprise11
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise10
Large Enterprise31
 

Questions from the Community

What needs improvement with Cloudflare Access?
Cloudflare Access has strong integration with Microsoft, among other platforms. However, when it comes to Kaspersky, ...
What is your primary use case for Cloudflare Access?
Cloudflare Access provides secure access to internal applications for employees, external members of the organization...
What advice do you have for others considering Cloudflare Access?
Cloudflare Access is one of the best integrations available. While about two hundred vendors offer similar services, ...
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, ...
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new ...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat De...
What needs improvement with Microsoft Defender for Office 365?
The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster.
What is your primary use case for Microsoft Defender for Office 365?
My use case for Microsoft Defender for Office 365 is for email protection, safe links, protection of links, documents...
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: April 2026.
886,011 professionals have used our research since 2012.