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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
25th
Average Rating
8.0
Reviews Sentiment
7.1
Number of Reviews
14
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of July 2025, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 12.3%, down from 16.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Enrique-Diaz Jolly - PeerSpot reviewer
Provides comprehensive threat protection with suggestions for modernizing controls
I use the email gateway as the core of the email exchange between the Internet and our domain. The email gateway serves as the email exchanger The product offers protection, email security, anti-spam, and antivirus. It includes threat intelligence with advanced malware protection and many…
Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Secure Email Threat Defense's scalability is good."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"It's very easy to deploy and configure."
"The solution is stable."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"It has an efficient email filtering feature."
"The product offers protection, email security, anti-spam, and antivirus."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"Our customers are satisfied with Defender for 365 because Microsoft products are easy to use and customize to meet the client's needs. Everything is in one place, so we can adjust policies as needed for phishing, DLP, ATP, or any other security features that our clients want to apply."
"The product is not resource-intensive."
"The two main features that prove most beneficial for us are URL scanning and attachment scanning."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"The initial setup is straightforward. You just add the license, click it, and then you can set up the rules. It is quite simple."
"Does a thorough job of examining email and URLs for malicious content."
"Microsoft Defender for Office 365 has improved my organization's security. It makes it easier to manage the infrastructure without the help of third-party applications."
"I would say that 90% of the spam and phishing attack emails get blocked right off the bat."
 

Cons

"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"This solution could be improved by integration with Sandbox."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"The pricing could always be better."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"Microsoft should provide more documentation for users so they can self-educate. I would like to see more documentation for advanced security features."
"The changes to customer service, specifically the new model for support agreements, are not favorable."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"There is a different console for different things; I just want one consolidated console."
"Configuration at the mid-level could be improved for the support team."
"Several simulation options are available within 365, and the phishing simulation could be better."
"Configuration requires going to a lot of places rather than just accessing one tab."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
 

Pricing and Cost Advice

"The solution’s pricing is manageable."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"The feedback from vendors and customer is that it is expensive."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"The product is expensive."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
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Top Industries

By visitors reading reviews
Computer Software Company
28%
Healthcare Company
8%
Government
6%
Manufacturing Company
5%
Computer Software Company
16%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher side. That said, you get what you pay for.
What needs improvement with Secure Email Threat Defense?
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty in sending logs to our SIEM. Cisco Secure Email Threat Defense's flexibility cou...
What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published. It's essential to enhan...
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: July 2025.
861,524 professionals have used our research since 2012.