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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
23rd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of September 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 5.2%, down from 11.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3655.2%
Cisco Secure Email Threat Defense1.1%
Other93.7%
Email Security
 

Featured Reviews

NM
Enginner at Millennium Information Technologies
Has faced challenges with configuration, taking actions, and learning curve but benefits from centralized management and good technical support
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, are limited as ETD only supports sending audit logs. Customers have requirements for other system logs as well, which should be developed from their side. Another customer request is to restrict the IPs that can log in, which cannot be done from Cisco Secure Email Threat Defense yet. Any user with login details can log in. We can restrict the IPs in Cloud Mail Gateways, but not from Cisco Secure Email Threat Defense. It would be beneficial to improve this feature. Cisco Secure Email Threat Defense can take actions, such as requesting O365 to quarantine mail. In that case, the customer requires notification to the recipient from Cisco Secure Email Threat Defense. This option would be valuable if available. The real-time threat intelligence of Cisco Secure Email Threat Defense is an AI-based classification. It took one to two months to optimize the classification, but we still experience some false positives. Reducing the learning period would be beneficial. The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned. Reducing the learning time would be much better. Additional features desired in the next release include IP restrictions and user logging IP restrictions, ensuring only the customer environment can log in to Cisco Secure Email Threat Defense. Logs forwarding needs improvement as currently it only has audit logs. In Cloud Mail Gateway, we can create an IPsec tunnel to forward logs. However, in Cisco Secure Email Threat Defense, there is no option, and we must do API integration to send logs. Only SIM can get logs; Syslog cannot retrieve them.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"It's very easy to deploy and configure."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"The product offers protection, email security, anti-spam, and antivirus."
"Secure Email Threat Defense's scalability is good."
"It has an efficient email filtering feature."
"The solution is stable."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"The feature I like the most about Microsoft Defender for Office 365 is that it typically runs in the background—you do not know it is there until you need to access it."
"The features I appreciate most about Microsoft Defender for Office 365 are admin notifications for potential threats along with protecting our Microsoft apps such as Outlook from potential phishing attacks."
"My experience with customer support and technical support for Microsoft Defender for Office 365 has been excellent."
"Microsoft Defender for Office 365 has decreased my time to detection and time to respond by one hundred percent."
"The product is not resource-intensive."
 

Cons

"The search area has room for improvement."
"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"We encounter issues while searching for missing emails."
"This solution could be improved by integration with Sandbox."
"In some situations, it has not been able to pick impersonated emails having no attachments. Technical support definitely has a scope for improvement."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"Configuring the default strategies and policies in Microsoft Defender for Cloud Apps generates a lot of noise and false positives."
"One area for improvement is support, in terms of being able to reach them and, especially, technical support for configuration."
"We noticed that from time to time, Microsoft's stability does have problems. Sometimes the service goes up and down. Sometimes they change without prior notice."
"Configuration at the mid-level could be improved for the support team."
"Sometimes, phishing emails manage to pass through the filter, so the system needs to enhance its phishing email detection capabilities."
 

Pricing and Cost Advice

"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The feedback from vendors and customer is that it is expensive."
"The solution’s pricing is manageable."
"It is expensive compared to other vendors."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"I know that the product is incredibly expensive."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"The product is very expensive."
"The product is expensive."
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Top Industries

By visitors reading reviews
Marketing Services Firm
11%
Outsourcing Company
9%
Construction Company
8%
Comms Service Provider
8%
Computer Software Company
11%
Manufacturing Company
9%
Financial Services Firm
9%
Comms Service Provider
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: August 2026.
911,839 professionals have used our research since 2012.