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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
20th
Average Rating
8.6
Reviews Sentiment
6.5
Number of Reviews
23
Ranking in other categories
Secure Web Gateways (SWG) (12th), Data Loss Prevention (DLP) (21st), Cloud Access Security Brokers (CASB) (13th), Distributed Denial-of-Service (DDoS) Protection (8th), Software Defined WAN (SD-WAN) Solutions (12th), Access Management (11th), Bot Management (3rd), ZTNA as a Service (9th), ZTNA (4th), Secure Access Service Edge (SASE) (10th), Remote Browser Isolation (RBI) (3rd)
Cisco Secure Email Threat D...
Ranking in Email Security
19th
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of June 2026, in the Email Security category, the mindshare of Cloudflare One is 1.6%, up from 1.6% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.1% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 6.3%, down from 12.6% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3656.3%
Cisco Secure Email Threat Defense1.1%
Cloudflare One1.6%
Other91.0%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
GC
Senior Cybersecurity Engineer at a financial services firm with 11-50 employees
Provides robust email security features but requires improved modernization and complexity management
Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Cloudflare Zero Trust Platform removes the risk of exposing the applications to the public."
"Cloudflare is by far the most effective solution that I have come across."
"Cloudflare Access is part of the Zero Trust philosophy."
"We mostly use Cloudflare WAF, and gets basic Cloudflaire DDoS, caching as extra bonus . We like the factor these features are all integrated into 1 console, simple to manage."
"For Cloudflare Access, I am using the free plan...The most valuable feature is their protection."
"Enables me to work from two locations."
"Cloudflare DDoS mitigates DDoS attacks."
"The blocking feature is very good."
"Cisco's technical support is very good."
"This solution is easy to use."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"It has an efficient email filtering feature."
"Secure Email Threat Defense's scalability is good."
"On ease of use, it rates very high."
"The features and functionalities are much better than Microsoft's in-built Defender plan, and this product has helped us to protect our organization from any malware attack in the past."
"Overall, it's certainly a very good idea to integrate another layer on top of Microsoft Advanced Threat Protection."
"The feature of Microsoft Defender for Office 365 that I like the most is probably the email features specifically, because those are the ones that a typical end user will accidentally click on a link not knowing what it is, and it'll catch it, and then it'll feed it over to Defender and stop the attack from happening before it actually can."
"The most valuable feature is protection against malicious links, fishing, and impersonation. You can train people to be aware of these threats, but they're not always careful. When they're using their phones between meetings, they click on a link, and it's game over."
"It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment."
"The solution is very easy to use. All you have to do is to assign the license to the end-user and it's done. The customer will only have the feature activated, and the solution will monitor the emails to determine if they are a threat or not."
"The email protection is excellent, especially in terms of anti-phishing policies."
"At the moment we are satisfied with this product. It's a stable, scalable, and resilient solution for us."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"Microsoft Defender for Office 365 is a cloud-based email filtering service that helps protect our organization against unknown malware and viruses by providing robust zero-day protection and includes features to safeguard our organization from harmful links in real-time."
 

Cons

"Operating and tuning the product is difficult."
"The response time for support must be reduced."
"They don't have a person to provide support for customers using the solution under their free plan."
"Cloudflare Zero Trust Platform needs to improve its documentation. It took time to do the implementation."
"The free plan has limitations. For example, I can only set up three rules, and the application firewall is unavailable."
"The software has automated alerts, but the automated alerts are not available in the mobile app."
"Cloudflare One is not very powerful, but for what we require, it is basic and sufficient."
"The pricing is an area that can be improved. Pricing, as far as I recall, was the source of our problems."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"We encounter issues while searching for missing emails."
"The search area has room for improvement."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"The visibility for the weaknesses in the system and unauthorized access can be improved."
"Sometimes I have to recategorize things when it takes the wrong step and I do not want it to classify something as suspicious."
"I assess the stability and reliability of the solution as seven out of ten."
"Configuration at the mid-level could be improved for the support team."
"Too many false positives and lacks an accurate capability to detect malicious SharePoint sites."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
"Sometimes, phishing emails manage to pass through the filter, so the system needs to enhance its phishing email detection capabilities."
 

Pricing and Cost Advice

"The solution is not that expensive."
"Cloudflare Zero Trust Platform's pricing is good."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"The prices are slightly expensive."
"The solution's pricing lacks transparency."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"It is expensive compared to other vendors."
"The feedback from vendors and customer is that it is expensive."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"The pricing is normal. Considering its popularity, it's not overpriced."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"The license is expensive because the cost is based on the number of users."
"The pricing has become expensive."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"I was working in the government and it was too expensive for us to use our Microsoft products."
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Top Industries

By visitors reading reviews
Construction Company
19%
Comms Service Provider
10%
Financial Services Firm
9%
Manufacturing Company
8%
Marketing Services Firm
12%
Manufacturing Company
8%
Computer Software Company
7%
Government
7%
Computer Software Company
12%
Manufacturing Company
9%
Financial Services Firm
9%
Comms Service Provider
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise1
Large Enterprise12
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
 

Questions from the Community

What needs improvement with Cloudflare Zero Trust Platform?
In my opinion, Cloudflare One can be improved mainly through compatibility, as the integration should be much simpler...
What is your primary use case for Cloudflare Zero Trust Platform?
Cloudflare One's primary use case for my organization is to protect servers and to provide remote access with the VPN...
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, ...
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new ...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat De...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking ...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: June 2026.
902,495 professionals have used our research since 2012.