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Cisco Secure Email Threat Defense vs Microsoft Exchange Online Protection (EOP) comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
23rd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Exchange Online P...
Ranking in Email Security
9th
Average Rating
8.2
Reviews Sentiment
6.6
Number of Reviews
42
Ranking in other categories
Anti-Malware Tools (13th)
 

Mindshare comparison

As of October 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Exchange Online Protection (EOP) is 3.0%, down from 5.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Exchange Online Protection (EOP)3.0%
Cisco Secure Email Threat Defense1.1%
Other95.9%
Email Security
 

Featured Reviews

GC
Senior Cybersecurity Engineer at a financial services firm with 11-50 employees
Provides robust email security features but requires improved modernization and complexity management
Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.
NancyHartman - PeerSpot reviewer
Business Process Manager/ Educational Technologist at a educational organization with 1,001-5,000 employees
Layered email security has protected sensitive research and still flags phishing in real time
The valuable features of Microsoft Exchange Online Protection (EOP) include providing an additional layer of protection, as it builds on the basic Exchange level of security that allows us to get our work done. Another feature I appreciate is the ability to question things, as our Exchange server allows us to identify in real-time if an email is a phishing email or spam email. It really helps us identify risks, especially through our external exchanges via email or through our cloud-based platforms. Our Exchange system blocks any embedded AI from all our applications and products, so we cannot use embedded AI in our daily work from our official laptops because we have secure information. The system is quite locked down.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The solution is stable."
"On ease of use, it rates very high."
"Overall, it's certainly a very good idea to integrate another layer on top of Microsoft Advanced Threat Protection."
"Cisco Secure Email Threat Defense's best features include user management of graymail, enhancing security awareness by allowing users to manage cold calls, sales-based items, and ensuring email compliance."
"The advanced threat analytics and URL filtering in threat detection are good features that are working well."
"Cisco's technical support is very good."
"This solution is easy to use."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"It has a really nice web-based administration console."
"It is useful for local users and our company because we use Microsoft 365."
"The scalability is pretty good; it does what it is supposed to do."
"The most valuable feature is the ease of administration. Other solutions require complex administration, but Microsoft Exchange Online Protection is easier."
"It's all running in the backend, so it doesn't affect the app functionality."
"With Microsoft Exchange Online Protection, if malware is attached to a mailer, it's very easy to go into the incident alert and find out what's happening with that identity and the mail."
"The initial setup of Microsoft Exchange Online Protection was easy."
"Microsoft EOP's most valuable feature is a shared mailbox."
 

Cons

"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"We encounter issues while searching for missing emails."
"The pricing could always be better."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"The product needs more granularity. Some features, like encryption, are not available."
"We have experienced issues while migrating from on-prem to the cloud. The tool needs to improve its stability."
"The price could be lower."
"I would like to get reports about vulnerable connections from our clients with information about domains, public IPs, etc. That would be highly useful."
"The security features could be better and more secure in the next release."
"Online Protection has an issue in that it doesn't provide an option to stop impersonation."
"Not all settings can be configured automatically and most still require manual configuration. However, there is an automation tool available that can be used to input all the configurations either as a script or a tool it would be helpful."
"Microsoft Exchange Online Protection is quite a difficult product."
 

Pricing and Cost Advice

"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The feedback from vendors and customer is that it is expensive."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"Apart from the license fee for the solution, there are no additional costs."
"On a scale of one to ten, where one is cheap, and ten is very expensive, I rate the pricing a six. For licensing, we can make monthly or yearly payments. Right now, we pay 5 USD per month to secure a person's license."
"It is a low-price solution."
"The product is expensive."
"Online Protection is fairly expensive."
"Microsoft Exchange Online Protection's pricing is a little bit more because its price has recently increased."
"The solution is priced high and could be less expensive compared to other solutions."
"The solution's pricing is subscription-based rather than a yearly licensing cost. Pricing is based on the size of the environment and company and can be expensive."
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Top Industries

By visitors reading reviews
Marketing Services Firm
11%
Outsourcing Company
9%
Comms Service Provider
9%
Healthcare Company
9%
Financial Services Firm
11%
Comms Service Provider
9%
Manufacturing Company
8%
Computer Software Company
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise6
Large Enterprise13
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What needs improvement with Microsoft Exchange Online Protection?
From an end-user point of view, I am quite happy with Microsoft Exchange Online Protection (EOP) because my favorite feature is the ease with which I can identify if an email is a phishing email or...
What is your primary use case for Microsoft Exchange Online Protection?
Microsoft Exchange Online Protection (EOP) serves as the main use case for my company because, as a research company, we require a very high level of security. We use multiple authentication method...
What advice do you have for others considering Microsoft Exchange Online Protection?
My experience with Microsoft Exchange Online Protection (EOP) is from an end-user perspective, and I do not have admin management experience. I am not familiar with the Advanced Threat Protection f...
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Microsoft EOP, MS Exchange Online Protection
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Information Not Available
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Exchange Online Protection (EOP) and other solutions. Updated: September 2026.
918,957 professionals have used our research since 2012.