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Microsoft Defender for Office 365 vs Palo Alto Networks VM-Series comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.4
Users found Microsoft Defender for Office 365 cost-effective, citing improved protection, time efficiency, and savings in security management.
Sentiment score
7.1
Palo Alto Networks VM-Series improves security, agility, and ROI, simplifying management with efficient deployment and minimal setup.
It has also decreased our time to detection and response by about 15 to 20 percent.
Customers can see data within a week, indicating a quick return on investment.
 

Customer Service

Sentiment score
6.9
Microsoft Defender for Office 365 offers knowledgeable support, though escalation delays and outdated documentation can affect resolution speed.
Sentiment score
7.5
Palo Alto Networks VM-Series customer service is praised for knowledge and speed but criticized for inconsistency and weekend delays.
Customer service and support have been fantastic.
The support quality could be improved.
The technical support is very good.
It is very hard to reach, and the process can be lengthy and frustrating because support involves several layers.
 

Scalability Issues

Sentiment score
8.1
Microsoft Defender for Office 365 is scalable, adaptable, and integrates seamlessly, supporting medium to large enterprises efficiently.
Sentiment score
7.4
Palo Alto Networks VM-Series is praised for scalability, adaptable licensing, and effective deployment, despite some resource management challenges.
They are easy to upgrade, and with credit licensing, they scale effectively according to demand.
If I were to rate it on a scale, it would receive nine out of ten, and with two-factor authentication, it would be ten.
 

Stability Issues

Sentiment score
7.8
Microsoft Defender for Office 365 is highly rated for stability, featuring strong performance and rare minor network issues.
Sentiment score
8.4
Palo Alto Networks VM-Series is praised for stability and reliability, despite occasional interface sluggishness and update challenges.
Hardware is generally very stable.
I have not experienced any major problems or downtime.
 

Room For Improvement

Microsoft Defender for Office 365 requires improvements in antivirus, scalability, integration, interface, threat intelligence, and licensing transparency.
Palo Alto Networks VM-Series struggles with interface, integration, pricing, scalability, Zero Trust, network configuration, documentation, and threat detection.
The main area for improvement is simplifying the implementation and rollout process.
I would reduce the cost.
Most customers go for partner-enabled support, which involves multiple layers, leading to delays.
There is a need for two-factor authentication, particularly for VPN and CloudProtect.
When managing the firewall, it involves a Strata Cloud web browser that requires improvement to enhance deployment ease and call center efficiency.
 

Setup Cost

Microsoft Defender for Office 365 pricing varies; often costly for SMBs but competitive for enterprises, with added licensing complexities.
Palo Alto Networks VM-Series offers valuable security but is costly; AWS Marketplace provides flexible purchase options.
Money-wise, it is a part of the Office 365 suite, making it slightly more expensive compared to Trend Micro.
The cost involves purchasing through a vendor, which might mark up due to the supply chain.
Palo Alto is expensive in terms of pricing, particularly when comparing features to cost.
The pricing is reasonable and reflects the quality of the product.
 

Valuable Features

Microsoft Defender for Office 365 provides comprehensive email protection with seamless Microsoft integration, enhancing threat management and data security.
Palo Alto Networks VM-Series offers robust threat management, advanced security, easy deployment, and superior integration with cloud services.
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
Microsoft Defender for Office 365 is now part of a centralized tenant for my entire group.
We use these tools to prevent all known and unknown threats using Palo Alto Networks' Wildfire and other data filtering tools to gather information, analyze traffic, manage malicious traffic, and offer visibility, control, and attack prevention.
Palo Alto's robust threat intelligence supports new updates, and I can open cases directly with their Threat Intelligence team.
Palo Alto Networks VM-Series is very strong in security features like antivirus, anti-spyware, and machine learning capabilities that help scan for antivirus and anti-spam.
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
1st
Average Rating
8.2
Reviews Sentiment
7.1
Number of Reviews
48
Ranking in other categories
Email Security (1st), Microsoft Security Suite (11th)
Palo Alto Networks VM-Series
Ranking in Advanced Threat Protection (ATP)
9th
Average Rating
8.6
Reviews Sentiment
7.1
Number of Reviews
61
Ranking in other categories
Firewalls (11th)
 

Mindshare comparison

As of April 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 9.2%, down from 15.0% compared to the previous year. The mindshare of Palo Alto Networks VM-Series is 2.0%, up from 0.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
AshwaniTyagi - PeerSpot reviewer
Advanced protection and good integration capabilities with good reliability
We use Palo Alto Networks VM-Series to offer services to our customers as a managed security service provider. We provide solutions and services to our customers across the globe. For example, if I want to host a firewall in the cloud or somewhere where the physical appliance is not a possibility…
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847,625 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
16%
Financial Services Firm
13%
Manufacturing Company
8%
Government
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
I don't have detailed specifics on pricing, setup cost, or licensing.
What needs improvement with Microsoft Defender for Office 365?
I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost.
Features comparison between Palo Alto and Fortinet firewalls
In the best tradition of these questions, Feature-wise both are quite similar, but each has things it's better at, it kind of depends what you value most. PA is good at app control, web filtering a...
How does Azure Firewall compare with Palo Alto Networks VM Series?
Both products are very stable and easily scalable. The setup of Azure Firewall is easy and very user-friendly and the overall cost is reasonable. Azure Firewall offers a solid threat awareness, can...
 

Also Known As

MS Defender for Office 365
No data available
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Warren Rogers Associates
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Palo Alto Networks VM-Series and other solutions. Updated: March 2025.
847,625 professionals have used our research since 2012.