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Microsoft Defender for Office 365 vs ThreatLocker Zero Trust Endpoint Protection Platform comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 19, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.4
Microsoft Defender for Office 365 enhances security, reduces costs, integrates effectively with Microsoft tools, and boosts productivity, offering significant ROI.
Sentiment score
8.1
ThreatLocker Platform boosts security, blocks ransomware, enhances control, and ensures swift value, reducing overhead for increased productivity and revenue.
It has also decreased our time to detection and response by about 15 to 20 percent.
If something were to happen without ThreatLocker, the cost would be huge, and thus, having it is definitely worth it.
The main return on investment is peace of mind, knowing that with ThreatLocker on any endpoint, it will almost always block all malicious code or exploits, even zero-day exploits.
It keeps malware, Trojans, and ransomware at bay.
 

Customer Service

Sentiment score
7.0
Microsoft Defender for Office 365 support is praised for responsiveness, though some users note templated responses and outdated documentation.
Sentiment score
8.8
ThreatLocker Zero Trust offers rapid support, with knowledgeable representatives providing efficient, real-time assistance and commendable Cyber Hero service.
Customer service and support have been fantastic.
They have been very responsive, helpful, and knowledgeable.
I would rate their customer support a ten out of ten.
Their support is world-class.
 

Scalability Issues

Sentiment score
8.1
Microsoft Defender for Office 365 is highly scalable and easily accommodates thousands of users without performance issues, simplifying growth.
Sentiment score
8.3
ThreatLocker offers scalable zero trust protection, easily deploying across endpoints, adapting efficiently to organizations' evolving security needs.
I started off with just the servers, and within a month and a half, I set up the entire company with ThreatLocker.
It seems to primarily operate on the endpoints rather than at a central location pushing out policies.
I would rate it a ten out of ten for scalability.
 

Stability Issues

Sentiment score
7.8
Microsoft Defender for Office 365 is reliable and stable, boasting 99.9% availability and prompt resolutions to minor bugs.
Sentiment score
7.5
ThreatLocker Zero Trust Platform offers stable, reliable service with minor issues, excellent integration, and responsive support, enhancing dependability.
For five years, we have not had a problem.
Once deployed, it downloads the policies locally, so even if the computer doesn't have internet, it doesn't matter.
They've worked through a lot of their issues and are pretty responsive in fixing them.
 

Room For Improvement

Microsoft Defender for Office 365 requires enhancements in virus blocking, phishing detection, integration, scalability, support, and pricing transparency.
ThreatLocker can enhance with flexible training, improved network management, user interface updates, optimized logging, and increased application support.
I would reduce the cost.
This is problematic when immediate attention is needed.
Comprehensive 24-hour log monitoring is a valuable enhancement for both business and enterprise-level users.
The company should strive to stay ahead of all the developments happening externally.
 

Setup Cost

Microsoft Defender for Office 365 is cost-effective for large enterprises but perceived as expensive for smaller businesses.
ThreatLocker Zero Trust Platform is praised for reasonable pricing, flexibility, value, and scalability, despite some renewal challenges.
After conversations with other partners, it became clear we underpriced it initially, which caused most of our issues.
We are moving towards the Unified solution, where they basically bundle everything together, providing us better stability with the ability to bring in new product offerings without having to go back to the customer and say, 'This is going to cost you.'
I had a really good deal at the time, and it continues to be cost-effective.
 

Valuable Features

Microsoft Defender for Office 365 provides comprehensive protection with seamless integration, simplifying security management and safeguarding remote work environments.
ThreatLocker enhances security with user-friendly features like allowlisting, ring-fencing, selective elevation, and efficient Cyber Hero support.
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent.
It protects our customers.
The major benefit is fewer breaches overall, as nothing can be run without prior approval. This helps my company protect its data and secure itself effectively.
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
1st
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
47
Ranking in other categories
Email Security (1st), Microsoft Security Suite (11th)
ThreatLocker Zero Trust End...
Ranking in Advanced Threat Protection (ATP)
7th
Average Rating
9.2
Reviews Sentiment
7.6
Number of Reviews
38
Ranking in other categories
Network Access Control (NAC) (5th), Endpoint Protection Platform (EPP) (10th), Application Control (3rd), ZTNA (6th), Ransomware Protection (4th)
 

Mindshare comparison

As of March 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 10.0%, down from 15.1% compared to the previous year. The mindshare of ThreatLocker Zero Trust Endpoint Protection Platform is 2.7%, up from 1.7% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Johnathan Bodily - PeerSpot reviewer
Ensures ransomware protection and reduces phishing chaos
The application control has been great so far, and while I am still exploring the network access controls, I unfortunately don't have access to one module I would love to have due to licensing restrictions. It's easy to use in regard to reducing attack surfaces. For me, it's a piece of cake. We can have something approved within 30 seconds, thanks to the mobile app. We haven't eliminated security solutions. We just add to it, and ThreatLocker has been a great addition. We also have Kaseya and ThreatLocker as a supplement to that. It's useful. They have overlap, and we look at the overlap as a good thing. It's helped your organization save on operational costs or expenses by ensuring that many fewer hours are spent dealing with ransomware nonsense. I cannot count the amount of hours that I personally have not had to put in to recovering an environment from a ransomware event. The last big one took us about three weeks to completely recover from. Since we've grouped ThreatLocker in, the management of that whole setup has gone down to just daily help desk tasks and general server maintenance instead of having the whole system on fire. There are probably thousands of hours of saved time between our teams. It's been great so far. ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications is great. It's my biggest protection, the blocked applications. In a lot of cases, you go to install something yourself that you need for management, and it comes in and says, nope. And then I have to log into the portal and approve it. I get our other guys saying, hey, why are you trying to approve something? Any of the tools that I'm using on a day-to-day basis that haven't been in the environment during the whole learning mode initially, I could go through and set extensions and all that. So, while it's a headache on that end, the amount of saved time I can't even count. It is a little frustrating on my end since I like to go as quickly as I possibly can, and it slows me down. However, that's a really good thing. Depending on the site, it can save a lot of time and cut down headaches. It's likely saved a week's worth of time. It's cut down the amount of sever help desk tickets. Those have become minimal.
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
38%
Retailer
8%
Financial Services Firm
6%
Manufacturing Company
5%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
I don't have detailed specifics on pricing, setup cost, or licensing.
What needs improvement with Microsoft Defender for Office 365?
I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost.
What do you like most about ThreatLocker Allowlisting?
The interface is clean and well-organized, making it simple to navigate and find what we need.
What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
We have encountered a few challenges regarding pricing, contract renewals, and additions. As we explored adding features like Cyber Hero, it proved to be an increased expense for our clients. This ...
What needs improvement with ThreatLocker Allowlisting?
I find that the learning mode is too accessible. Technicians sometimes default to it instead of manually building policy controls. I would prefer the learning mode to be harder to access, ideally h...
 

Also Known As

MS Defender for Office 365
Protect, Allowlisting, Network Control, Ringfencing
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Information Not Available
Find out what your peers are saying about Microsoft Defender for Office 365 vs. ThreatLocker Zero Trust Endpoint Protection Platform and other solutions. Updated: March 2025.
841,714 professionals have used our research since 2012.